Dolphin is the most popular Wii and GameCube emulator for PC, Mac, Linux, and even Android. It can run Punch-Out!! perfectly at high resolutions.
Brief overview of the Wii’s storage system, WBFS (Wii Backup File System), its purpose in homebrew and modding scenes, and the legal tensions between format conversion, backup rights, and copyright law. punch-out wii rom wbfs
If the game black screens, change the "Game Load" setting in USB Loader GX to "cIOS 249" (base 56) or "cIOS 250" (base 57). Dolphin is the most popular Wii and GameCube