The tour grossed over $22 million, proving that hip-hop could achieve the same arena-level commercial success as major rock bands like U2 or the Rolling Stones . It is widely considered one of the most successful and professional rap tours ever produced.

The Up In Smoke Tour 2000 has left an enduring legacy in hip-hop history, with many regarding it as one of the greatest concert tours of all time. The tour's influence can be seen in subsequent hip-hop tours and festivals, such as the Angry Mob Tour and the Loot Festival. The event's impact on hip-hop culture extends beyond the music itself, as it helped to bring people together and create a sense of community and shared experience.

Billed as the definitive hip-hop spectacle of the new millennium, the tour was a massive, high-budget production headlined by the "Holy Trinity" of West Coast rap: , with a scene-stealing supporting turn from a then-rising Eminem .