In the same Compatibility tab, check the box for Run this program as an administrator to ensure it has permission to save your progress.
Assuming this is a graphics or rendering tool (based on the "Mayachan" association), configuration is usually the trickiest part because portable apps don't automatically set up system paths. together with mayachan final sheablesoft portable
18;write_to_target_document7;default18;write_to_target_document1a;_KDvuabXkF6K3wN4Pv9jT8QQ_20;a5; 0;5074;0;4c57; In the same Compatibility tab, check the box