In this report we describe:
| Parameter | Method | Result | |-------------------------|-------------------------------------|--------| | Aqueous solubility (pH 7.4) | Kinetic shake‑flask (25 °C) | 12 µM | | Log D 7.4 (octanol/water) | HPLC‑based pH‑stat | 2.1 | | PAMPA permeability | Parallel artificial membrane assay | 1.8 × 10⁻⁶ cm s⁻¹ | | Microsomal stability (human) | 30 min incubation with pooled HLM, NADPH | t½ = 85 min | | CYP inhibition (IC₅₀) | Panel of CYP3A4, 2C9, 2D6 | >10 µM (no inhibition) | JUQ-139